Association of Oxidative Stress Markers with Vascular Stiffness Parameters in Patients with Diabetic Neuropathy

Introduction: One of the most common chronic complications diabetes mellitus is diabetic neuropathy. The aim study was to elucidate association between selected markers oxidative stress and vascular stiffness contribute understanding pathophysiological links micro- macrovascular diabetes. Methods: We enrolled patients with type 2 DM (n = 49), moderate severe polyneuropathy lower extremities, a control group without microvascular 29). neuropathy received alpha-lipoic acid infusion therapy. Sampling performed before after treatment determine level (advanced glycation end-products—AGEs, products AOPP proteins, MDA malondialdehyde oxidized LDL), parameters metabolic wall were measured by sphygmomanometry. Results: After administration acid, we demonstrated significant reduction in three oxidation (AOPP: p < 0.001, AGE: oxLDL: 0.05). In contrast, did not change significantly (p 0.83). Throughout group, oxLDL correlated central BP (SBP DBP aorta, 0.05 <0.01) augmentation index (AiX/75 bpm, 0.01). systolic aorta find associations remaining markers. Conclusion: our study, also an damage lipids proteins (oxLDL AOPP) some stiffness.